Project management and dissemination

Workpackage 1

Objectives

• To ensure that the project objectives are met on schedule and within budgetary limits.
• To ensure that the project's deliverables meet the high scientific quality standards set.
• To ensure that reports are delivered to the EC on time and with contents as required.
• To work for gender equality and to take care of science and society issues of the project.
• To facilitate adequate dissemination of the project's results.
• To promote exploitation of the project's results.
• To ensure good communication between MSCNET and the European Myeloma Network.
• To facilitate contact and interaction between basic and clinical myeloma research groups, both within and outside of MSCNET.
• To prepare guidelines and standard procedures for techniques and methods.

Description of work

• Overall scientific, legal, financial, and administrative management of the project.
• Monitoring inter-workpackage alignment.
• Preparation of the progress reports to the EC.
• Function as liaison to the EC on behalf of the consortium in all verbal and written communication.
• Periodic monitoring of the progress towards the projects' objectives and initiation of corrective measures as and when appropriate
• Dissemination of project's results.
• Function as the consortium's formal contact with the European Myeloma Network (EMN).
• Represent the consortium in contact with external organizations, the press and with the general public.
• Based on our partnership we will establish a workshop on multiparametric flow cytometry and cell sorting to discuss the technical and methodological problems with focus on guidelines and recommendations for identification and sorting of the different B subsets, from different samples and different disease stages.

Deliverables

• Periodic EC reports first period (Activity reports, management reports, reports on distribution of EC contribution).
• Periodic EC reports second period.
• Periodic EC reports third period.
• Publication in per-reviewed international scientific journals.
• Presentations at international scientific conferences.
• Presentation of MSCNET project and progress on EMN's web site.
• A panel of antibodies and a flow cytometry strategy identifying the B cell hierarchy.
• A sorting strategy establishing single cell libraries by global RT-PCR.
• A set of Q-PCR test identifying CD genes and oncogenes - to qualify the libraries.
• Standard operating Procedures for different tissue, disease stages and disease type.

Milestones and expected result

• When the Project Management Office and the Workpackage leaders are operational.
• When the report for the first reporting period has been approved.
• When the report for the second reporting period has been approved.
• When the report for the final reporting period has been approved.
• When the project's results have been adequately disseminated.
• When the project's objectives have been realized.
• When a recommendation and a standard operating procedure for flow cytometry identification and sorting of normal and myeloma B cell subsets has been published.
• When a standard procedure for single cell sorting has been disseminated.